MCQ: Immunology 3 with Answers

In this section, you can find 18 questions (from 20 to 38) from various topics of Immunology. The answers of these questions are given at the end of this blog post.
20. Pollen would most likely evoke which type of hypersensitivity response:
a. Cytotoxic (Type II)
  b. Immune complex (Type III)
  c. Cell Mediated (Type IV)
d. Immediate type (Type I)
  e. latent (Type V).
21. Which hypersensitivity reactions are T cell mediated?
a. Type I     b. Type II    c. Type III    d. Type IV    e. None of these
22. Which of the following bind to mast cells and cross-link, resulting in de-granulation and release of histamine?
a. IgM           b. IgA             c. IgG          d. Interleukins    e. IgE
23. Theoretically, type………… blood can be donated to all persons because it lacks…………
a. O/antigens b. AB/ antibodies c. A/ antibodies d. O/antibodies e. A/IgE
24. Type II hypersensitivity is due to:
a. IgE         b. Activation of cytotoxic T cells             c. Pollen            d. IgM  e. Mismatched blood types in transfusion
25. Production of auto-antibodies may be due to:
a. Emergence of mutant clones of B cells b. Production of antibodies against sequestered (hidden) tissues     c. genetic factors d. all are possible
e. None of these
26.A positive tuberculin test is an example of
a. Type I hypersensitivity b. Delayed type hypersensitivity c. acute contact dermatitis d. Eczema e. Pollen allergic response
27. Rheumatoid arthritis is an ……….disease that affects the……….
a. Allergic/ cartilage b. Autoimmune/nerves c. Autoimmune/ joints
d. Immunodeficiency/ muscles e. Allergic/ muscles
28. Contact with poison ivy would elicit which type of hypersensitivity reaction?
a. type III b. type I c. type II d. type IV e. type V
29. A tissue graft between two people who are not genetically identical is termed a:
a.Isograft b. Heterograft c. Xenograft d. Autograft e. Allograft
  • An “isograft is performed between genetically identical individuals (i.e. monozygotic twins).
  • A “heterograft”is not a word that is used in transplantation immunology.
  • A “xenograft” is a transplant that is performed across species.
  • An “autograft”  is a transplant from one location in the body to another.
  • An allograft  is a transplant between two members of the same species who are not genetically identical.So option “e” is the right answer.
30. An example of a type III immune complex disease is:
a. Contact dermatitis b. Graft rejection c. Serum sickness d. Atopy  e. Allergies
31. Graft versus host disease results when the recipient lacks or has a poor immune system, and the donor organ and recipient express different:
a. HLA   b. T cells    c. Antibodies   d. Autoantibodies   e. Interleukins
32. Agammaglobulinemia is an immunodeficiency disease due to a deficiency in:
a. T cells b. MHC c. IgE d. Cytokines e. B cells
33. Which disease would be most similar to AIDS in its pathology?
a. SCID          b. DiGeorge Syndrome         c. Agammaglobulinemia     d. ADA deficiency e. Kuru
34. Human immunodeficiency virus (HIV) binds specifically to which immune cell marker?
a. CD8        b. MHC         c. CDC          d. CD4            e. GP120
35. HIV has a high mutation rate due to the imprecise operation of its:
a. Viral membrane         b. CD4 receptor              c. Reverse transcriptase d. protease e. dismutase
36. Pregnancy test detects the presence of which of the following?
a. Rh           b. Human Chorionic Gonadotropoin (HCG) c. Fetal proteins
d. Agglutination e. Depuration factor
37. Which of the following is considered an autoimmune disease?
a. rheumatoid arthritis b. AIDS c. SCID d. agammaglobulinemia e. CJD
38. A transplant between individuals of different animal species is termed a:
a. allograft b. isograft c. enterograft d. endograft e. xenograft

Answer Keys

20.d Immediate type (Type I)
21.d Type IV
22.e IgE
23.a O/antigens
24.e. Mismatched blood types in transfusion
25.d. all are possible
26.b. Delayed type hypersensitivity
27.c. Autoimmune/ joints
28.d. type IV
29.e. Allograft
30.c. Serum sickness
31.a. HLA
32.e. B cell
33.a. SCID
34.d. CD4
35.c. Reverse transcriptase
36.b. Human Chorionic Gonadotropoin (HCG)
37.a. rheumatoid arthritis
38.e. xenograft

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