MCQ Immunology (56-70): Hypersensitivity Answers with Explanations

In this section, you can find 18 questions (from 300 to 318) on various topics of Immunology. The answers to these questions are given at the end of this blog post.  

56. Pollen would most likely evoke which type of hypersensitivity response:
a. Cytotoxic (Type II)
b. Immune complex (Type III)
c. Cell-Mediated (Type IV)
d. Immediate type (Type I)
e. latent (Type V)

57. Which hypersensitivity reactions are T cell-mediated?
a. Type I
b. Type II
c. Type III  
d. Type IV
e. None of these

58. Which of the following bind to mast cells and cross-link, resulting in degranulation and release of histamine?
a. IgM
b. IgA
c. IgG
d. Interleukins
e. IgE  

59. Theoretically, type………… blood can be donated to all persons because it lacks…………
a. O/antigens
b. AB/ antibodies
c. A/ antibodies
d. O/antibodies
e. A/IgE  

60. Type II hypersensitivity is due to:
a. IgE
b. Activation of cytotoxic T cells
c. Pollen
d. IgM
e. Mismatched blood types in transfusion  

61. Production of autoantibodies may be due to:
a. Emergence of mutant clones of B cells
b. Production of antibodies against sequestered (hidden) tissues
c. Genetic factors
d. All are possible
e. None of these  

62. A positive tuberculin test is an example of
a. Type I hypersensitivity
b. Delayed type hypersensitivity
c. Acute contact dermatitis
d. Eczema
e. Pollen allergic response  

63. Rheumatoid arthritis is an ……….disease that affects the……….
a. Allergic/cartilage
b. Autoimmune/nerves
c. Autoimmune/joints
d. Immunodeficiency/muscles
e. Allergic/muscles  

64. Contact with poison ivy would elicit which type of hypersensitivity reaction?
a. type III
b. type I
c. type II
d. type IV
e. type V  

65. A tissue graft between two people who are not genetically identical is termed a:
a. Isograft
b. Heterograft
c. Xenograft
d. Autograft
e. Allograft

66. An example of type III immune complex disease is:
a. Contact dermatitis
b. Graft rejection
c. Serum sickness
d. Atopy
e. Allergies

67. Graft versus host disease results when the recipient lacks or has a poor immune system, and the donor organ and recipient express different:
a. HLA
b. T cells
c. Antibodies
d. Autoantibodies
e. Interleukins  

68. Agammaglobulinemia is an immunodeficiency disease due to a deficiency in:
a. T cells
b. MHC
c. IgE
d. Cytokines
e. B cells  

69. Which disease would be most similar to AIDS in its pathology?
a. SCID
b. DiGeorge Syndrome
c. Agammaglobulinemia
d. ADA deficiency
e. Kuru  

70. Human immunodeficiency virus (HIV) binds specifically to which immune cell marker?
a. CD8
b. MHC
c. CDC
d. CD4
e. GP120

BONUS QUESTIONS

Bonus 1. HIV has a high mutation rate due to the imprecise operation of its:
a. Viral membrane
b. CD4 receptor
c. Reverse transcriptase
d. protease
e. dismutase  

Bonus 2. Which of the following is considered an autoimmune disease?
a. rheumatoid arthritis
b. AIDS
c. SCID
d. agammaglobulinemia
e. CJD  

Bonus 3. A transplant between individuals of different animal species is termed as:
a. allograft
b. isograft
c. enterograft
d. endograft
e. xenograft  

If you want to try more MCQs in Immunology, follow this link: MCQ in Immunology (71-85): Basic Concepts

Answer Keys

56.d Immediate type (Type I)
57.d Type IV
58.e IgE
59.a O/antigens
60.e. Mismatched blood types in transfusion
61.d. all are possible
62.b. Delayed type hypersensitivity
63.c. Autoimmune/ joints
64.d. type IV
65.e. Allograft
Explanation:  

• An “isograft“ is performed between genetically identical individuals (i.e. monozygotic twins).
• A “heterograft” is not a word that is used in transplantation immunology.
• A “xenograft” is a transplant that is performed across species.
• An “autograft”  is a transplant from one location in the body to another.
• An allograft is a transplant between two members of the same species who are not genetically identical. So option “e” is the right answer.

66.c. Serum sickness
67.a. HLA
68.e. B cell
69.a. SCID
70.d. CD4

Answers to Bonus Questions

Bonus 1.c. Reverse transcriptase
Bonus 2.a. rheumatoid arthritis
Bonus 3.e. xenograft