Japanese Encephalitis (JE) Virus: Life Cycle, Pathogenesis, Diagnosis

By Acharya Tankeshwar •  Updated: 06/06/21 •  4 min read

Japanese Encephalitis (JE) virus was initially isolated in Japan in 1935. It is a leading cause of vaccine-preventable encephalitis (inflammation of the brain parenchyma) in Asia and the western Pacific.


The virus is maintained in an enzootic cycle between mosquitoes and amplifying vertebrate hosts (mainly pigs). The highest risk months for JE transmission are August, September, and early October.

Properties of JE Virus

Structure of Japanese Encephalitis Virus
Structure of Japanese encephalitis virus (JEV)

Transmission Cycle of Japanese Encephalitis Virus 

Fig: Japanese Encephalitis Virus Life Cycle
Fig: Japanese Encephalitis Virus Life Cycle

Population at risk

In endemic countries: 

Clinical Feature (sign/symptoms)

Fig: Geographic Distribution of Japanese Encephalitis Virus
Fig: Geographic distribution of Japanese encephalitis virus

30%–50% of people with encephalitis develop permanent neurologic or psychiatric sequelae.

Diagnosis of Japanese Encephalitis

Diagnosis of Japanese encephalitis is based on a combination of clinical signs and symptoms and specialized laboratory tests of blood or CSF.


JE Vaccine


Acharya Tankeshwar

Hello, thank you for visiting my blog. I am Tankeshwar Acharya. Blogging is my passion. As an asst. professor, I am teaching microbiology and immunology to medical and nursing students at PAHS, Nepal. I have been working as a microbiologist at Patan hospital for more than 10 years.

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