Krebs Cycle: Steps and Products

By Ashma Shrestha •  Updated: 05/13/22 •  3 min read

The Krebs cycle is an aerobic cycle of breaking down acetyl CoA. Each cycle yields a molecule of FADH₂ (flavin adenine dinucleotide+ H₂), a molecule of GTP (guanosine triphosphate), three molecules of NADH (nicotinamide adenine dinucleotide + hydrogen) , and two molecules of carbon dioxide. The aerobic breakdown of pyruvate (final product of glycolysis), beta oxidation of fatty acids, and catabolism of amino acids results in the formation of acetyl CoA. Krebs cycle occurs inside the mitochondrial matrix of the eukaryotic cell and in the cytoplasm of prokaryotic cells.

Krebs cycle is also known as the TCA (Tricarboxylic acid) cycle or citric acid cycle because citric acid is produced in the first step which has 3 carboxyl (-COOH) groups.

Steps of Krebs Cycle

Krebs cycle is amphibolic; catabolism (breakdown) and anabolism (synthesis) co-occur. 


Products of Krebs Cycle

A molecule of acetyl CoA gives following products:

From the process of oxidative phosphorylation a molecule FADH₂ produces 1.5 ATP and a molecule of NADH produces 2.5 ATP. So, Krebs cycle produce almost 10 ATP from a molecule of acetyl CoA.

Reference and Further Reading

Ashma Shrestha

Hello, I am Ashma Shrestha. I am currently pursuing my Master's Degree in Microbiology. Passionate about writing and blogging. Key interest in virology and molecular biology

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