MCQ Immunology (56-70): Hypersensitivity Answers with Explanations

In this section, you can find 18 questions (from 300 to 318) on various topics of Immunology. The answers to these questions are given at the end of this blog post.  

**56. Pollen would most likely evoke which type of hypersensitivity response:**a. Cytotoxic (Type II)b. Immune complex (Type III)c. Cell-Mediated (Type IV)d. Immediate type (Type I)e. latent (Type V)

**57. Which hypersensitivity reactions are T cell-mediated?**a. Type Ib. Type IIc. Type III   d. Type IVe. None of these

**58. Which of the following bind to mast cells and cross-link, resulting in degranulation and release of histamine?**a. IgMb. IgAc. IgGd. Interleukinse. IgE

**59. Theoretically, type………… blood can be donated to all persons because it lacks…………**a. O/antigensb. AB/ antibodiesc. A/ antibodiesd. O/antibodiese. A/IgE

**60.Type II hypersensitivityis due to:a. IgEb. Activation of cytotoxic T cellsc. Pollend. IgMe.**Mismatched blood types in transfusion

**61. Production of autoantibodies may be due to:**a. Emergence of mutant clones of B cellsb. Production of antibodies against sequestered (hidden) tissuesc. Genetic factorsd. All are possiblee. None of these

62. A positivetuberculin testis an example ofa. Type I hypersensitivityb. Delayed type hypersensitivityc. Acute contact dermatitisd. Eczemae. Pollen allergic response

**63. Rheumatoid arthritis is an ……….disease that affects the……….**a. Allergic/cartilageb. Autoimmune/nervesc. Autoimmune/jointsd. Immunodeficiency/musclese. Allergic/muscles

**64. Contact with poison ivy would elicit which type of hypersensitivity reaction?**a. type IIIb. type Ic. type IId. type IVe. type V

65. A tissue graft between two people who are not genetically identical is termed a:a. Isograftb. Heterograftc. Xenograftd. Autografte. Allograft

**66. An example of type III immune complex disease is:**a. Contact dermatitisb. Graft rejectionc. Serum sicknessd. Atopye. Allergies

**67. Graft versus host disease results when the recipient lacks or has a poor immune system, and the donor organ and recipient express different:**a. HLAb. T cellsc. Antibodiesd. Autoantibodiese. Interleukins

**68. Agammaglobulinemia is an immunodeficiency disease due to a deficiency in:**a. T cellsb. MHCc. IgEd. Cytokinese. B cells

**69. Which disease would be most similar to AIDS in its pathology?**a. SCIDb. DiGeorge Syndromec. Agammaglobulinemiad. ADA deficiencye. Kuru

**70.Human immunodeficiency virus (HIV)binds specifically to which immune cell marker?**a. CD8b. MHCc. CDCd. CD4e. GP120

BONUS QUESTIONS

**Bonus 1. HIV has a highmutation ratedue to the imprecise operation of its:**a. Viral membraneb. CD4 receptorc. Reverse transcriptased. proteasee. dismutase

**Bonus 2. Which of the following is considered an autoimmune disease?**a. rheumatoid arthritisb. AIDSc. SCIDd. agammaglobulinemiae. CJD

**Bonus 3. A transplant between individuals of different animal species is termed as:**a. allograftb. isograftc. enterograftd. endografte. xenograft  

If you want to try more MCQs in Immunology, follow this link:MCQ in Immunology (71-85): Basic Concepts

Answer Keys

56.d Immediate type (Type I)57.d Type IV58.e IgE59.a O/antigens60.e. Mismatched blood types in transfusion61.d. all are possible62.b. Delayed type hypersensitivity63.c. Autoimmune/ joints64.d. type IV65.e. AllograftExplanation:

• An “isograft*“* is performed between genetically identical individuals (i.e. monozygotic twins).
• A “heterograft” is not a word that is used in transplantation immunology.
• A “xenograft” is a transplant that is performed across species.
• An “autograft”  is a transplant from one location in the body to another.
• An allograft is a transplant between two members of the same species who are not genetically identical. So option “e” is the right answer.

66.c. Serum sickness67.a. HLA68.e. B cell69.a. SCID70.d. CD4

Answers to Bonus Questions

Bonus 1.c. Reverse transcriptaseBonus 2.a. rheumatoid arthritisBonus 3.e. xenograft

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