MCQ in Virology: Hepatitis and Related Viruses

In this blog, I have posted few multiple-choice questions regarding Hepatitis virus properties, lab diagnosis, vaccine, etc. Some of the below posted questions are simple to solve if you apply simple logic as you can find the right answer by excluding wrong answers, even if you don’t know the right answer, but if you know the background information required to solve those questions. But some questions are quite tricky and you are likely to be prey, by choosing the option, which was provided to entice you to click and trap.

I am not posting right answers of those questions right now, because it kills your creativity and your reading habit, just give a try. If any confusion you can ask me later.

  1. …….. are the only viruses that produce genome DNA by reverse transcription with mRNA as the template.
    a. Hepadnaviruses
    b. Retroviruses
    c. Influenza viruses
    d. SARS viruses
  2. ……….. virus is also known as enterovirus 72?
    a. Hepatitis A
    b. Hepatitis E
    c. Polio
    d. Rota
  3. ………… virus is a defective virus?
    a. Influenza
    b. SARS
    c. Marburg
    d. Hepatitis D
  4. Which of the following statement about the hepatitis virus is not right?
    a. Chronic carriage of HBV is much higher than the rate of chronic carriage of HCV
    b. Hepatitis D Virus has only one serotype because HBsAg has only one serotype
    c. Hepatitis E virus does not have carrier prolong carrier stage
    d. Person immunized against HBV will not be infected by Hepatitis D Virus
  5. Which of the following statement regarding Hepatitis B Immune globulin (HBIG) is not correct?
    a. Hepatitis B Immune globulin (HBIG) contains a high titer of HBsAb
    b. HBIG is prepared from sera of patients who are recovered from hepatitis B.
    c. HBIG is used to provide immediate, passive protection to individuals
    d. HBIG is not recommended to give to a newborn whose mother is HBsAg positive, because their blood already contains HBsAb.  
  6. Which of the following statement regarding Hepatitis Virus culture is right?
    a. Both Hepatitis A virus and Hepatitis C Virus have not yet been grown to cell culture
    b. Hepatitis A virus can be grown in cell culture but Hepatitis C virus has not yet been grown in cell culture.
    c. Hepatitis C virus can be grown in cell culture but Hepatitis A virus has not yet been grown in cell culture.
    d. None of the Hepatitis virus (HAV, HBV, HCV, HDV, HGV) grows in cell culture.  
  7. Which of the following statement(s) regarding laboratory diagnosis of Hepatitis virus is/are misleading?
    a. Recombinant Immunoblot Assay (RIBA) is one of the confirmatory test used to diagnose HCV infection
    b. The most important laboratory test for the detection of early HBV infection is the immunoassay for HBsAg
    c. The detection of IgG antibody in patients serum is the most important test for presumptive diagnosis of HAV infection
    d. The diagnosis of HDV Infection in the laboratory can be made by detecting delta antigen.
  8. Which one of the following statements regarding hepatitis B virus (HBV) is most accurate?

a. The most reliable indicator that a person can transmit HBV is the presence of HBsAg in the blood.
b. HBV has a circular, partially double-stranded DNA as its genome and has a DNA polymerase in the virion.
c. HBV infection induces Antibody to HBcAg (core antigen) protects from re-infection by same strains of HBV.
d. A person in the “window period” can be diagnosed as having been infected by HBV if HBsAg is present.

9. Which one of the following statements regarding hepatitis C virus (HCV) is most accurate?

a. Chronic infection with HCV predisposes to hepatocellular carcinoma.
b. HCV is a defective virus that requires concurrent HBV infection in order to replicate.
c. Chronic infection with HCV occurs less frequently than chronic infection with HBV.
d. Proper sewage disposal has significantly decreased the incidence of hepatitis C.

10. Which one of the following statements regarding hepatitis D virus (HDV) is most accurate?

a. Alpha interferon can eradicate the latent state established by HDV.
b. Immunization against hepatitis B virus (HBV) will reduce the incidence of hepatitis caused by HDV.
c. HDV has DNA as its genome and an RNA-dependent DNA polymerase in the virion.
d. Laboratory diagnosis of HDV infection is made by growing HDV in cells coinfected with HBV.

Answer Keys

  1. b (retroviruses)
  2. a (hepatitis A virus)
  3. d (hepatitis D virus)
  4. try yourself
  5. try yourself
  6. try yourself
  7. try yourself
  8. b
  9. a
  10. b

Acharya Tankeshwar

Hello, thank you for visiting my blog. I am Tankeshwar Acharya. Blogging is my passion. As an asst. professor, I am teaching microbiology and immunology to medical and nursing students at PAHS, Nepal. I have been working as a microbiologist at Patan hospital for more than 10 years.

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