Science is not perfect nor does all those breakthrough discoveries. Those beliefs that we have right now about a particular thing, person, event, or discovery may change anytime soon if new research gives sufficient evidence against it. For many years, scientific communities, the press, and the general public believed/ blamed Gaëtan Dugas as a “Patient Zero” but recently he was exonerated, thanks to a recent article published in the journal ‘Nature’. After recovering and analyzing viral RNA from archival samples of the 1970s, and using phylogenetic tools such as Bayesian phylogenetic analyses, a group of scientists tried to refute widespread misinterpretation that he infected many people with HIV-1.
The term ‘patient zero’ is used to denote an original or primary case of a disease.
Researchers refute Patient 0 claim in the writing in Nature, “We also recovered the HIV-1 genome from the individual known as ‘Patient Zero’ and found neither biological nor historical evidence that he was the primary case in the US or for subtype B as a whole.
Who was Gaëtan Dugas?
Gaëtan Dugas was a gay Air Canada flight attendant. He was supposed to have thousands of sexual partners mostly males across North America. It was told that at least 40 of the 248 people diagnosed with AIDS by April 1982 were thought to have had sex either with him or with someone he had. He was blamed as “Patient Zero”: the man who supposedly introduced AIDS to the United States. Journalist Randy Shilts described Dugas as “the Quebeçois version of Typhoid Mary” and labeled him as a villain and sinner whose reckless sexual behavior helped the AIDS epidemic to take hold.
In 1993 a film was made based on the best-selling book by Randy Shilts ” And the Band Played On: Politics, People, and the AIDS Epidemic”
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Some historians even wrote Dugas had “sown the disease and death all along his route, at the rate of about 250 partners per year.” Dugas died on March 30, 1984, at the age of 30 years.
How he is free from blame now?
Scientists who published this recent article in nature serologically screened more than 2000 1970s serum samples. They recovered HIV RNA and after phylogenetic analysis found that the US HIV-1 epidemic exhibited extensive genetic diversity.
The initial introduction of HIV 1 subtype B lineage into the Caribbean was from Africa. HIV virus first spreads to New York and subsequently to different locations in the United States. Genetic sequencing of viral RNA showed that the strain infecting him had circulated among gay men in New York for several years before he arrived in 1974. Therefore, although Dugas had hundreds of sexual partners in several cities, he did not introduce the virus to North America. Scientists found no evidence to tell that Patient 0 was the first person infected by this lineage of HIV-1.
Further Reading and References
- MCKAY RA, “Patient Zero”: The Absence of a Patient’s View of the Early North American AIDS Epidemic. (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046389/)
- Worobey M et al.1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America (Link: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19827.html)