Multiple Choice Questions on Basic Immunology Concepts

I have here presented fifteen Multiple Choice Questions from the Immunology sections. These MCQs are collected via various sources and some of the MCQs i have prepared myself. I have posted the key (right answers) of some of the questions, and left some others for you to try and expolore.

1.       Pattern recognition receptors (PRR) include:
A.      Lectin-like molecules
B.      Lipoteichoic acid
C.      LPS
D.      PAMPs
E.       Unmethylated CpG sequences

2.       The mononuclear phagocyte system does not include:
A.      Endothelial cells.
B.      Kidney mesangial cells.
C.      Kupffer cells.
D.      Lymph node medullary macrophages.
E.       Monocytes.

3.       A polymorphonuclear neutrophil (PMN):
A.      Is a bone marrow stem cell.
B.      Is closely similar to a mast cell.
C.      Contains microbicidal cytoplasmic granules.
D.      Is not a professional phagocytic cell.
E.       Has granules which stain with eosin.
4.       Plasma cells are a specific type of immune cells which plays major role in Antibody mediated immunity.
This plasma cell secretes:
A.      Antibody of a single specificity related to that on the surface of the parent B-cell
B.      Antibody of two antigen specificities
C.      The antigen it recognizes
D.      Many different types of antibody
E.       Lysozyme

5.       Neutrophil defensins are:
A.      Anti-toxins.
B.      Oxygen-dependent.
C.      Enzymes.
D.      Glycolipids.
E.       Peptide antibiotics.

6.       Lysozyme:
A.      Is a cytoplasmic organelle.
B.      Activates complement.
C.      Is a proteolytic enzyme.
D.      Splits peptidoglycan.
E.       Is released by mast cells.
7.       Which of the following is not an acute phase protein:
A.      Chondroitin sulfate.
B.      C-reactive protein.
C.      Fibrinogen.
D.      Mannose binding lectin.
E.       Serum amyloid P component.

8.       Interferons:
A.      Are divided into 5 main families.
B.      Are found only in mammalian species.
C.      Are specific for individual viruses.
D.      Induce enzyme synthesis in the target cell.
E.       Only affect infected cells.

9.       Natural killer (NK) cells do not:
A.      Contain perforin.
B.      Contain serine proteases.
C.      Contain tumor necrosis factor (TNF).
D.      Kill only by damaging the target cell outer membrane.
E.       Respond to interferon.

10.   Polymorphonuclear neutrophils attack bacteria:
A.      By phagocytosis.
B.      By secreting complement.
C.      By secreting interferon.
D.      Exclusively by oxygen-dependent mechanisms.
E.       Exclusively by oxygen-independent mechanisms.

11.   Acute inflammation can be initiated by:
A.      An increase in vascular permeability.
B.      C3.
C.      Influx of neutrophils.
D.      Lysozyme.
E.       Mast cell activation.

12.   Clonal selection occurs when antigen is encountered by:
A.      Basophils
B.      Eosinophils
C.      Mast cells
D.      Neutrophils
E.       T-cells

13.    The major function of Plasma cells is to secrete large amounts of antibody.
Which of the following statements regarding plasma cells is correct?
A.      Are derived from T-cells
B.      Develop into B-cells
C.      Have a highly developed rough endoplasmic reticulum
D.      Have a thin layer of cytoplasm
E.       Secrete large amounts of gamma interferon

14.   After the contact with foreign antigens, body produces specific antibody.
These specific antibodies are readily detectable in serum following primary contact with antigen after:
A.      10 min
B.      1 h
C.      5–7 days
D.      3–5 weeks
E.       Only following a second contact with antigen

15.   Adoptive transfer of acquired immune responsiveness involves the transfer of:
A.      Antibody
B.      Complement
C.      Phagocytes
D.      Lymphocytes
E.       Serum

Answer Keys of Basic Immunology Concepts Questions:

  1. A.      Lectin-like molecules.
  2. A.      Endothelial cells.
  3. C.      Contains microbicidal cytoplasmic granules.
  4. Try yourself
  5. Try yourself
  6. D.      Splits peptidoglycan.
  7. A.      Chondroitin sulfate.
  8. D.      Induce enzyme synthesis in the target cell.
  9. D.      Kill only by damaging the target cell outer membrane.
  10. Try yourself
  11. Try yourself
  12. E.       T-cells
  13. Try yourself
  14. C.      5–7 days
  15. D.      Lymphocytes

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